Short-echo-time 1H MRS studies of alcohol exposure on the mouse brain over-expressing glutamate dehydrogenase
نویسنده
چکیده
W-T. Wang, S-P. Lee, E. Michaelis, and I-Y. Choi Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, 1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, United States, Department of Neurology, Molecular & Integrative Physiology, Hoglund Brain Imaging Center, Kasnas City, KS, United States
منابع مشابه
Detection of Glutamate Alterations in the Human Brain Using 1H-MRS: Comparison of STEAM and sLASER at 7 T
PURPOSE To assess reproducibility of glutamate measurement in the human brain by two short echo time (TE) 1H-MRS sequences [stimulated echo acquisition mode (STEAM) and semi-localized by adiabatic selective refocusing (sLASER)] at 7 T. Reliable assessment of glutamate is important when studying a variety of neurological and neuropsychiatric disorders. At 7 T, the glutamate signal can be separat...
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BACKGROUND Proton magnetic resonance spectroscopy (1H MRS) allows measurement of alcohol in the human brain after alcohol consumption. However, the quantity of alcohol that can be detected in the brain by 1H MRS pulse sequences has been controversial, with values ranging from about 24% to 94% of the temporally concordant blood alcohol concentrations. The quantitation of brain alcohol is critica...
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